HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(m-Tolyl)piperazine → Methyl {2-[4-(3-methylphenyl)piperazin-1-yl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrido[3,4-d]pyrimidin-4-yl}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(m-Tolyl)piperazine | HCID 83111 | — |
| Reactant | HCID 86620420 | HCID 86620420 | — |
| Product | Methyl {2-[4-(3-methylphenyl)piperazin-1-yl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrido[3,4-d]pyrimidin-4-yl}acetate | HCID 59168064 | — |
Reaction Steps
Starting from 250 mg (0.34 mmol) of the carbodiimide from Example 17A and 63 mg (0.36 mmol) of 3-methylphenylpiperazine, general procedure [C] and purification by preparative HPLC result in 88 mg (48% of theory) of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198282B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-7349df4989394a219d8c041abe85adb2 |
| Source note | uspto-grants-2012_06 |