HRID217659

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81430

N-(3-Methoxyphenyl)piperazine

C11H16N2O

结构：COC(=O)/C=C/c1ccncc1N=C=Nc1cccc(C(F)(F)F)c1

HCID86620420

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CC1c2ccncc2N=C(N2CCN(c3cccc(OC)c3)CC2)N1c1cccc(C(F)(F)F)c1

HCID59168068

未命名化合物

PROCEDURE

实验过程

Starting from 250 mg (0.34 mmol) of the carbodiimide from Example 17A and 69 mg (0.36 mmol) of 3-methoxyphenylpiperazine, general procedure [C] and purification by preparative HPLC result in 90 mg (46% of theory) of product.

WORKUP

后处理

customresult in 90 mg (46% of theory) of product

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3bac9fde47644ba4a013dc0600039706
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08198282B2
来源说明: uspto-grants-2012_06

反应 SMILES

[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([N:9]=[C:10]=[N:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][C:17]=2/[CH:18]=[CH:19]/[C:20]([O:22][CH3:23])=[O:21])[CH:6]=[CH:7][CH:8]=1.[CH3:26][O:27][C:28]1[CH:29]=[C:30]([N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[CH:31]=[CH:32][CH:33]=1>>[CH3:26][O:27][C:28]1[CH:29]=[C:30]([N:34]2[CH2:39][CH2:38][N:37]([C:10]3[N:9]([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:24])([F:1])[F:25])[CH:4]=4)[CH:18]([CH2:19][C:20]([O:22][CH3:23])=[O:21])[C:17]4[CH:16]=[CH:15][N:14]=[CH:13][C:12]=4[N:11]=3)[CH2:36][CH2:35]2)[CH:31]=[CH:32][CH:33]=1