N-(3-methoxyphenyl)piperazine → HCID 59168058, compound

HRID 217661Notes

Reaction equation

HRID 217661 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([N:9]=[C:10]=[N:11][C:12]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2/[CH:18]=[CH:19]/[C:20]([O:22][CH3:23])=[O:21])[CH:6]=[CH:7][CH:8]=1.[CH3:26][O:27][C:28]1[CH:29]=[C:30]([N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[CH:31]=[CH:32][CH:33]=1>>[CH3:26][O:27][C:28]1[CH:29]=[C:30]([N:34]2[CH2:39][CH2:38][N:37]([C:10]3[N:9]([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:24])([F:1])[F:25])[CH:4]=4)[CH:18]([CH2:19][C:20]([O:22][CH3:23])=[O:21])[C:13]4[CH:14]=[N:15][CH:16]=[CH:17][C:12]=4[N:11]=3)[CH2:36][CH2:35]2)[CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 81430N-(3-methoxyphenyl)piperazineHCID 86620419HCID 86620419, compound

Product 1

HCID 59168058HCID 59168058, compound

Procedure

Starting from 107 mg (0.31 mmol) of the carbodiimide from Example 15A and 59 mg (0.31 mmol) of 3-methoxyphenylpiperazine, general procedure [C] and purification by preparative HPLC result in 40 mg (23% of theory) of product.

Workup

  1. customresult in 40 mg (23% of theory) of product

Sources & evidence

ORD record
ord-4aa74d9e771849959b12c67445b35581
Source dataset
uspto-grants-2012_06
Patent number
US08198282B2

Reaction notes

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