HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2176700Generated: October 31, 2026
Hydrazine → 5-Chloro-3-fluoro-2-hydrazinylpyridine
https://huagongshe.com/reaction/2176700
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 5-Chloro-2,3-difluoropyridine | HCID 2783248 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 5-Chloro-3-fluoro-2-hydrazinylpyridine | HCID 22619674 | — |
Reaction Steps
A mixture of 5-chloro-2,3-difluoropyridine (10.0 g, 66.9 mmol) and hydrazine (10.0 ml, 319 mmol) in iPrOH (50 mL) was heated to 65-70° C. for 6 hours. The mixture was cooled to 23° C., filtered, and washed with Na2CO3 (satd), and H2O. Product isolated as a white solid. MS (ESI pos. ion) m/z: 162 (MH+). Calc'd exact mass for C5H5ClFN3: 161.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09066954B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-5e7f9f73775b4885b69e83adc24e10b1 |
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| Source note | uspto-grants-2015_06 |
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