Carbon Dioxide → 5-Aminosalicylic Acid

Participants

Reaction Conditions

Reaction Steps

p-Acetaminophenol 15 g, lithium hydroxide 60 g, and aluminum oxide 45 g were added into a 500 ml autoclave, and CO2 was introduced to perform a carboxylation reaction under a reaction pressure of 3.0 MPa and heated to 190° C., maintained for 2 hours, then the reaction was terminated, cooled to 80° C., and 1500 ml distilled water was added to dissolve lithium 5-aminosalicylate. After decolorization, the aqueous phase was acidified with 20˜30% hydrochloric acid until pH=4, cooled and then filtered to obtain the product of 5-aminosalicylic acid, the content is 99% and the yield is 85%.

Provenance & Evidence