Carbon Dioxide → 5-Aminosalicylic Acid

Participants

Reaction Conditions

Reaction Steps

p-Acetaminophenol 15 g, potassium hydroxide 37.5 g, and diatomite 90 g were added into a 500 ml autoclave, and CO2 was introduced to perform a carboxylation reaction under a reaction pressure of 5.0 MPa and heated to 210° C., maintained for 1 hour, then the reaction was terminated, cooled to 80° C., and 1500 ml distilled water was added to dissolve potassium 5-aminosalicylate. After decolorization, the aqueous phase was acidified with 20˜30% sulfuric acid until pH=4, cooled and then filtered to obtain the product of 5-aminosalicylic acid, the content is 96% and the yield is 92%.

Provenance & Evidence