Carbon Dioxide → 5-Aminosalicylic Acid

Participants

Reaction Conditions

Reaction Steps

p-Acetaminophenol 15 g, sodium hydroxide 22.5 g, and aluminum oxide 15 g were added into a 500 ml autoclave, and CO2 was introduced to perform a carboxylation reaction under a reaction pressure of 3.0 MPa and heated to 170° C., maintained for 3 hours, then the reaction was terminated, cooled to 80° C., and 1500 ml distilled water was added to dissolve sodium 5-aminosalicylate. After decolorization, the aqueous phase was acidified with 20˜30% nitric acid until pH=4, cooled and then filtered to obtain the product of 5-aminosalicylic acid, the content is 97% and the yield is 75%.

Provenance & Evidence