Dimethyl 5-aminoisophthalate → HCID 67174306, compound

Participants

Reaction Steps

Dimethyl 5-aminoisophthalate (obtained from Aldrich Chemical Co., Milwaukee, Wis., 0.441 g, 2.12 mmol) was dissolved in dry N,N-dimethylformamide (8 mL) in a 50 mL round-bottom flask under inert atmosphere. A 2.12 Molar solution of octadecylisocyanate (2.12 mmol) in dry N,N-dimethylformamide (1 mL) was then added dropwise. The residual octadecylisocyanate solution was quantitatively transferred with 2 portions of N,N-dimethylformamide (1 mL each) and the reaction was stirred overnight at room temperature. The reaction was then heated to 100° C. for 22 h, and thereafter cooled to room temperature to give a white slurry. The solid was then vacuum filtered, washed with fresh N,N-dimethylformamide, and then washed with deionized water. The filtrate was concentrated by rotary evaporation to give a white solid.

Provenance & Evidence