HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylglycine → (3aR,4S,7aR)-4-(2-dimethylamino-acetoxy)-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylglycine | HCID 673 | — |
| Reactant | (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester | HCID 68276168 | — |
| Product | (3aR,4S,7aR)-4-(2-dimethylamino-acetoxy)-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester | HCID 60141604 | — |
Reaction Steps
Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and dimethylamino acetic acid to yield (3aR,4S,7aR)-4-(2-dimethylamino-acetoxy)-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester. MS [M+H] 296 (ester elimination ion); Rt 4.592 min; LC-MS Method II
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067881B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-cef8412708c247df82ab7b043efeeded |
| Source note | uspto-grants-2015_06 |