Imidazole-1-acetic acid → HCID 60142173, compound

HRID 2176754Notes

Reaction equation

HRID 2176754 reaction equation
[CH3:1][O:2][C:3]([N:5]1[C@@H:13]2[C@@H:8]([C@@:9]([OH:23])([C:14]#[C:15][C:16]3[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12]2)[CH2:7][CH2:6]1)=[O:4].[N:24]1([CH2:29][C:30](O)=[O:31])[CH:28]=[CH:27][N:26]=[CH:25]1>>[CH3:1][O:2][C:3]([N:5]1[C@H:13]2[C@H:8]([C@:9]([O:23][C:30](=[O:31])[CH2:29][N:24]3[CH:28]=[CH:27][N:26]=[CH:25]3)([C:14]#[C:15][C:16]3[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12]2)[CH2:7][CH2:6]1)=[O:4]

Participants

3

Reactant 2

HCID 656129Imidazole-1-acetic acidHCID 68276168(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester

Product 1

HCID 60142173HCID 60142173, compound

Procedure

Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and 2-(1H-imidazol-1-yl)acetic acid to yield (3aR,4S,7aR)-4-(2-imidazol-1-yl-acetoxy)-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester. MS [M+H]=422; RT=5.152 min; LC-MS Method III

Sources & evidence

ORD record
ord-6b394f75233e4c75a0a17b3b2bd4f864
Source dataset
uspto-grants-2015_06
Patent number
US09067881B2

Reaction notes

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