HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-3-Oxopropanoic Acid → (3aR,4S,7aR)-methyl 4-(3-amino-3-oxopropanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-3-Oxopropanoic Acid | HCID 75367 | — |
| Reactant | (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester | HCID 68276168 | — |
| Product | (3aR,4S,7aR)-methyl 4-(3-amino-3-oxopropanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate | HCID 60142969 | — |
Reaction Steps
Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and 3-amino-3-oxopropanoic acid to yield (3aR,4S,7aR)-methyl 4-(3-amino-3-oxopropanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate. MS [M+H]=296 (ester elimination ion); RT=0.96 min; UPLC Method I
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067881B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-b1c794b8d2714a25ae0152902c08d774 |
| Source note | uspto-grants-2015_06 |