1-Pyrrolidinebutanoic acid → HCID 60143102, compound

HRID 2176786Notes

Reaction equation

HRID 2176786 reaction equation
[CH3:1][O:2][C:3]([N:5]1[C@@H:13]2[C@@H:8]([C@@:9]([OH:23])([C:14]#[C:15][C:16]3[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12]2)[CH2:7][CH2:6]1)=[O:4].[N:24]1([CH2:29][CH2:30][CH2:31][C:32](O)=[O:33])[CH2:28][CH2:27][CH2:26][CH2:25]1>>[N:24]1([CH2:29][CH2:30][CH2:31][C:32]([O:23][C@@:9]2([C:14]#[C:15][C:16]3[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12][C@@H:13]3[C@H:8]2[CH2:7][CH2:6][N:5]3[C:3]([O:2][CH3:1])=[O:4])=[O:33])[CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 148556811-Pyrrolidinebutanoic acidHCID 68276168(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester

Product 1

HCID 60143102HCID 60143102, compound

Procedure

Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and 4-pyrrolidin-1-yl-butyric acid to yield (3aR,4S,7aR)-methyl 4-(4-(pyrrolidin-1-yl)butanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate. MS [M+H]=453; RT=0.96 min; UPLC Method I

Sources & evidence

ORD record
ord-65c3d5eaa63f4bec9080ae329b9bf045
Source dataset
uspto-grants-2015_06
Patent number
US09067881B2

Reaction notes

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