59481-43-5 → HCID 60141044, compound

HRID 2176790Notes

Reaction equation

HRID 2176790 reaction equation
[CH3:1][O:2][C:3]([N:5]1[C@@H:13]2[C@@H:8]([C@@:9]([OH:23])([C:14]#[C:15][C:16]3[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12]2)[CH2:7][CH2:6]1)=[O:4].[CH:24]([NH:27][C:28]([CH2:30][CH2:31][CH2:32][C:33](O)=[O:34])=[O:29])([CH3:26])[CH3:25]>>[CH:24]([NH:27][C:28](=[O:29])[CH2:30][CH2:31][CH2:32][C:33]([O:23][C@@:9]1([C:14]#[C:15][C:16]2[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=2)[CH2:10][CH2:11][CH2:12][C@@H:13]2[C@H:8]1[CH2:7][CH2:6][N:5]2[C:3]([O:2][CH3:1])=[O:4])=[O:34])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 345939459481-43-5HCID 68276168(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester

Product 1

HCID 60141044HCID 60141044, compound

Procedure

Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and 4-isopropylcarbamoyl-butyric acid to yield (3aR,4S,7aR)-methyl 4-(5-(isopropylamino)-5-oxopentanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate. MS [2M+H]=938; RT=1.18 min; UPLC Method I

Sources & evidence

ORD record
ord-f9ae0d624b0743e298b064c8249b2d35
Source dataset
uspto-grants-2015_06
Patent number
US09067881B2

Reaction notes

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