30436-23-8 → HCID 60141046, compound

HRID 2176793Notes

Reaction equation

HRID 2176793 reaction equation
[CH3:1][O:2][C:3]([N:5]1[C@@H:13]2[C@@H:8]([C@@:9]([OH:23])([C:14]#[C:15][C:16]3[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12]2)[CH2:7][CH2:6]1)=[O:4].[CH2:24]([N:26]([CH2:35][CH3:36])[C:27]([CH2:29][CH2:30][CH2:31][C:32](O)=[O:33])=[O:28])[CH3:25]>>[CH2:35]([N:26]([CH2:24][CH3:25])[C:27](=[O:28])[CH2:29][CH2:30][CH2:31][C:32]([O:23][C@@:9]1([C:14]#[C:15][C:16]2[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=2)[CH2:10][CH2:11][CH2:12][C@@H:13]2[C@H:8]1[CH2:7][CH2:6][N:5]2[C:3]([O:2][CH3:1])=[O:4])=[O:33])[CH3:36]

Participants

3

Reactant 2

HCID 505787630436-23-8HCID 68276168(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester

Product 1

HCID 60141046HCID 60141046, compound

Procedure

Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and 4-diethylcarbamoyl-butyric acid to yield (3aR,4S,7aR)-methyl 4-(5-(diethylamino)-5-oxopentanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate. MS [2M+NH4]=982; RT=1.23 min; UPLC Method I

Sources & evidence

ORD record
ord-708fbe3398f94e2db72612287cc5742e
Source dataset
uspto-grants-2015_06
Patent number
US09067881B2

Reaction notes

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