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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2176794Generated: October 25, 2026

4-(Dipropylcarbamoyl)butanoic acid → (3aR,4S,7aR)-methyl 4-(5-(dipropylamino)-5-oxopentanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate

https://huagongshe.com/reaction/2176794

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Dipropylcarbamoyl)butanoic acidHCID 16772901—
Reactant(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl esterHCID 68276168—
Product(3aR,4S,7aR)-methyl 4-(5-(dipropylamino)-5-oxopentanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylateHCID 60141047—

Reaction Steps

Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and 4-dipropylcarbamoyl-butyric acid to yield (3aR,4S,7aR)-methyl 4-(5-(dipropylamino)-5-oxopentanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate. MS [2M+H+NH4]=1039; RT=1.41 min; UPLC Method I

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09067881B2
Source datasetuspto-grants-2015_06
ORD IDord-6e6596db2b384b368dec7bdcf0d6d97c
Source noteuspto-grants-2015_06