Pyrrolidin-1-ylacetic acid → HCID 60141473, compound

HRID 2176805Notes

Reaction equation

HRID 2176805 reaction equation
[CH3:1][O:2][C:3]([N:5]1[C@@H:13]2[C@@H:8]([C@@:9]([OH:23])([C:14]#[C:15][C:16]3[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12]2)[CH2:7][CH2:6]1)=[O:4].[N:24]1([CH2:29][C:30](O)=[O:31])[CH2:28][CH2:27][CH2:26][CH2:25]1>>[N:24]1([CH2:29][C:30]([O:23][C@@:9]2([C:14]#[C:15][C:16]3[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=3)[CH2:10][CH2:11][CH2:12][C@@H:13]3[C@H:8]2[CH2:7][CH2:6][N:5]3[C:3]([O:2][CH3:1])=[O:4])=[O:31])[CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 414564Pyrrolidin-1-ylacetic acidHCID 68276168(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester

Product 1

HCID 60141473HCID 60141473, compound

Procedure

Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and pyrrolidin-1-yl-acetic acid to yield (3aR,4S,7aR)-methyl 4-(2-(pyrrolidin-1-yl)acetoxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate. MS [M+H] 425; RT=4.954 min; LCMS Method III

Sources & evidence

ORD record
ord-72fb38524e7d468c9bbacd3397b35da3
Source dataset
uspto-grants-2015_06
Patent number
US09067881B2

Reaction notes

Loading…