Potassium Carbonate → HCID 59287316, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromo-4,6-dimethylpyridine (1 g, 5.4 mmol), 4-bromo-3-fluoro-phenol (1.03 g, 5.4 mmol), and potassium carbonate (0.89 g, 6.4 mmol) was heated at 150° C. (oil bath temperature) in a sealed tube for 7 days. After cooling to room temperature the mixture was diluted with DCM and filtered through a diatomaceous earth pad. The filtrate was evaporated till dryness and the crude product thus obtained was purified by column chromatography (silica gel; DCM as eluent). The desired fractions were collected and evaporated in vacuo to yield intermediate 7 (1.1 g, 53%).

Provenance & Evidence