3-(2-Fluoro-4-nitrophenoxy)-2,6-dimethyl-pyridine → 4-(2,6-Dimethyl-pyridin-3-yloxy)-3-fluoro-phenylamine

Participants

Reaction Steps

A solution of intermediate 9 (5.88 g, 22.44 mmol) in ethanol (200 ml) was hydrogenated at room temperature in the presence of palladium 10% on activated carbon (0.58 g) for 3 hours. The solids were filtered off and the filtrate was evaporated till dryness to yield intermediate 10 (5.20 g, >99%) that was used without further purification.

Provenance & Evidence