反应详情

Aqueous ammonia was added to solution of 2-cyclohexylacetyl chloride (500 mg, 3.11 mmol) in CHCl3 (10 ml). After completion of reaction, the reaction mixture was diluted with CHCl3 (2×30 ml). The organic layer was washed with saturated sodium bicarbonate solution, brine and dried over anhydrous sodium sulfate. The organic layer was concentrated under vacuum, crude compound was washed with hexane (2×8 ml) and dried to afford 400 mg (87.8%) of 2-cyclohexylacetamide.

1. customAfter completion of reaction
2. washThe organic layer was washed with saturated sodium bicarbonate solution, brine
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationThe organic layer was concentrated under vacuum, crude compound
5. washwas washed with hexane (2×8 ml)
6. customdried