Ammonia → HCID 19063441, compound

HRID 2176885Notes

Reaction equation

HRID 2176885 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([CH3:13])[C:8](OCC)=[O:9])=[CH:3][CH:2]=1.[NH3:14]>>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([CH3:13])[C:8]([NH2:14])=[O:9])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 11651240Ethyl 2-(pyridin-4-yl)propanoate

Product 1

HCID 19063441HCID 19063441, compoundYield 38.8%

Conditions

Temperature
70 °C

Procedure

Methanolic ammonia (20 ml) was added to ethyl 2-(pyridin-4-yl)propanoate (140 mg, 0.78 mmol) in a steel bomb. The reaction mixture was heated to 70° C. for 18 h, then the temperature of the reaction was brought down to room temperature and the volatiles were evaporated. The reaction mixture was washed with n-pentane to afford 45 mg (38.8%) of 2-(pyridin-4-yl)propanamide as an orange color solid.

Workup

  1. customwas brought down to room temperature
  2. customthe volatiles were evaporated
  3. washThe reaction mixture was washed with n-pentane

Sources & evidence

ORD record
ord-c54b3dfffbd0401bb93473d550714e82
Source dataset
uspto-grants-2015_06
Patent number
US09067888B2

Reaction notes

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