Cyanogen Bromide → HCID 51000386, compound

HRID 217689Notes

Reaction equation

HRID 217689 reaction equation
[NH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)[NH2:2].[N:9]#[C:10][Br:11]>CCO.O.CCO.O>[BrH:11].[N:1]1[N:2]=[C:10]([NH2:9])[N:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=12

Participants

6

Reactant 2

HCID 10476Cyanogen BromideHCID 786452-Hydrazinopyridine

Product 1

HCID 51000386HCID 51000386, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolvent2×HCID 19096565Water ethanolSolvent

Procedure

2-Hydrazinopyridine (654 mg) was dissolved in a mixture of EtOH and water (7.5/1.5 ml) at RT while stirring. Subsequently, cyanogen bromide solution (666 mg dissolved in a mixture of EtOH/water 1.5/0.3 ml) was added dropwise while stirring. After stirring at RT for 6 h, the solvent was drawn off, and the residue was taken up in water and freeze-dried. 1.3 g of the title compound were obtained. LC-MS rt: 0.15 min [M+H]+: 135.3 (met. a)

Workup

  1. additionwas added dropwise
  2. stirringwhile stirring
  3. stirringAfter stirring at RT for 6 h
  4. customfreeze-dried

Sources & evidence

ORD record
ord-23043b16255f460cbbfa83e341341922
Source dataset
uspto-grants-2012_06
Patent number
US08198272B2

Reaction notes

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