Ammonia → HCID 21973937, compound

HRID 2176892Notes

Reaction equation

HRID 2176892 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([CH3:14])[CH2:8][C:9](OCC)=[O:10])=[CH:3][CH:2]=1.[NH3:15]>>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([CH3:14])[CH2:8][C:9]([NH2:15])=[O:10])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22277801Ethyl 3-(pyridin-4-yl)butanoate

Product 1

HCID 21973937HCID 21973937, compoundYield 47%

Procedure

A solution of ethyl 3-(pyridin-4-yl)butanoate (0.50 g, 2.59 mmol) in methanolic ammonia (10 ml) was heated to 100° C. in a pressure bomb for 48 h. The solvent was evaporated under reduced pressure to afford the crude compound, which was washed with n-pentane and dried under reduced pressure to afford 0.2 g (47%) of 3-(pyridin-4-yl)butanamide as an off-white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customto afford the crude compound, which
  3. washwas washed with n-pentane
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-bae163c026e14c37a50e9d65809f4649
Source dataset
uspto-grants-2015_06
Patent number
US09067888B2

Reaction notes

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