Diethyl 2-(4-(4-methylpiperazin-1-yl)benzyl)-2-methylmalonate → 2-(4-(4-Methylpiperazin-1-yl)benzyl)propanoic acid

Participants

Reaction Steps

A solution of diethyl 2-(4-(4-methylpiperazin-1-yl)benzyl)-2-methylmalonate (1.50 g, 4.29 mmol) in conc. HCl (10 ml) was stirred at 130-140° C. in a sealed tube for 18 h. The reaction mixture was concentrated and co-distilled with toluene to afford 700 mg (63.6%) of 2-(4-(4-methylpiperazin-1-yl)benzyl)propanoic acid as dark brown solid.

Provenance & Evidence