Ammonia → HCID 66869527, compound

HRID 2176927Notes

Reaction equation

HRID 2176927 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[C:12]([CH2:14][C:15]([O:17]C)=O)[CH:11]=[CH:10][N:9]=2)[CH2:4][CH2:3]1.[NH3:19]>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[C:12]([CH2:14][C:15]([NH2:19])=[O:17])[CH:11]=[CH:10][N:9]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 67382772HCID 67382772, compound

Product 1

HCID 66869527HCID 66869527, compoundYield 31%

Procedure

A solution of methyl 2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)acetate (750 mg, 2.81 mmol) in methanolic ammonia (10 ml) was heated in a steel bomb at 90° C. for 72 h. The reaction mixture was cooled to room temperature, concentrated and dried in vacuum to afford the crude product. Purification by triturating with diethyl ether afforded 370 mg (31%) of 2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)acetamide as a light brown color solid.

Workup

  1. concentrationconcentrated
  2. customdried in vacuum
  3. customto afford the crude product
  4. customPurification
  5. customby triturating with diethyl ether

Sources & evidence

ORD record
ord-2ac5e599c5ff4ea392a173141b015e22
Source dataset
uspto-grants-2015_06
Patent number
US09067888B2

Reaction notes

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