Ammonia → HCID 178513947, compound

Participants

Reaction Conditions

Reaction Steps

cis-Methyl 4-(phenylamino)cyclohexanecarboxylate (0.50 g, 2.14 mmol) was dissolved in methanolic ammonia (15 ml) in a pressure bomb and heated at 100° C. for three days. The reaction mixture was cooled to room temperature and concentrated under reduced pressure to afford the crude compound which was washed with n-pentane and dried in vacuo to afford 300 mg (63%) of cis-4-(phenylamino)cyclohexanecarboxamide as white solid.

Provenance & Evidence