HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonic acid-guanidine (1:1) → HCID 2824489, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonic acid-guanidine (1:1) | HCID 286947 | — |
| Reactant | 2-Fluoro-6-(4-methylbenzyloxy)benzonitrile | HCID 2737386 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 2824489 | HCID 2824489 | 37.8% |
Reaction Steps
2-Fluoro-6-(4-methylbenzyloxy)benzonitrile (241.3 mg; 1 mmol) and guanidine carbonate (180.2 mg; 1 mmol) were heated at 145° C. in dimethyl acetamide for 7 hours. The solvent was removed. Purification by recrystallization in hot ethanol/water yielded 106 milligrams of 5-(4-methylbenzyloxy)quinazoline-2,4-diamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067897B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-653a3df0e3514ecbb7a5705957d014ee |
| Source note | uspto-grants-2015_06 |