HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetylpyridine → alpha-Methyl-2-pyridinemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetylpyridine | HCID 14286 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | alpha-Methyl-2-pyridinemethanol | HCID 86784 | 12.3% |
Reaction Steps
Sodium borohydride (344 mg; 9.08 mmol) was added portionwise to a solution of 2-acetylpyridine (500.0 mg; 8.25 mmol) in methanol. The reaction mixture was stirred overnight at room temperature. Quenched with water and extracted with ethyl acetate and solvent removed to yield 125 milligrams of 1-(2-pyridyl)ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067897B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-fd9fa215f860440d8008eed936a51261 |
| Source note | uspto-grants-2015_06 |