反应详情

Sodium borohydride (111 mg, 2.9 mmol) was added in portions to a solution of 1-(4-chlorophenyl)-2-methoxy-ethanone (1 g, 6.4 mmol) in methanol at room temperature. After 1 hour, reaction was quenched with 3 mls (aq) sat. NH4Cl. Water was added to dissolve the inorganic and mixture was extracted with ethyl acetate 3×5 ml. Combined organics were washed with brine (2×3 ml) and dried over MgSO4. Crude material was obtained upon filtration and concentration to an amber oil which was purified by flash silica gel and eluted with 10-17% EA/Hex gradient. 1-(4-chlorophenyl)-2-methoxy-ethan-1-ol was obtained as an amber oil (370 mg, 68% yield).

1. customreaction
2. customwas quenched with 3 mls (aq) sat. NH4Cl
3. additionWater was added
4. dissolutionto dissolve the inorganic and mixture
5. extractionwas extracted with ethyl acetate 3×5 ml
6. washCombined organics were washed with brine (2×3 ml)
7. dry with materialdried over MgSO4
8. customCrude material was obtained upon filtration and concentration to an amber oil which
9. customwas purified by flash silica gel
10. washeluted with 10-17% EA/Hex gradient