Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate → HCID 90418545, compound

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Reaction Steps

The title compound was prepared according to the procedure described in Example 1 starting following Step 5 and 6 coupling [3-(3,3-difluorocyclopentyl)-5-(trifluoromethyl)-1,2-thiazol-4-yl]methanol and ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate followed by hydrolysis to afford the desired product as an off-white solid. 1H NMR (300 MHz, CD3OD) δ 6.90-6.98 (m, 2H), 5.22 (s, 2H), 3.88-3.94 (m, 1H), 2.89 (t, J=7.5 Hz, 2H), 2.50-2.64 (m, 4H), 2.20-2.41 (m, 4H). 19F NMR (300 MHz, CD3OD) δ−56.37, −90.10, −90.91, −130.13. Mass spectrum (ESI, m/z): Calcd. for C19H16F7NO3S, 470.1 (M−H). found 470.1.

Provenance & Evidence