HCID 12437435, compound → HCID 12437453, compound

HRID 2177213Notes

Reaction equation

HRID 2177213 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]([OH:15])=[O:14])=[C:11](C(O)=O)[S:10][N:9]=2)=[CH:4][CH:3]=1>ClC1C=CC=CC=1Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([C:13]([OH:15])=[O:14])=[CH:11][S:10][N:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 12437435HCID 12437435, compound

Product 1

HCID 12437453HCID 12437453, compound

Reagents, catalysts & solvents 1

HCID 72391,2-DichlorobenzeneSolvent

Conditions

Temperature
200 °C

Procedure

Into a 50-mL round-bottom flask, was placed 3-(4-chlorophenyl)-1,2-thiazole-4,5-dicarboxylic acid (1.8697 g, 6.74 mmol, 1.00 equiv), 1,2-dichlorobenzene (20 mL). The resulting solution was stirred for 20 min at 200° C. The resulting mixture was concentrated, and then added 30 mL of petroleum ether slowly when it is hot. The solids were collected by filtration, washed with petroleum ether. This resulted in 1.35 g (86%) of 3-(4-chlorophenyl)-1,2-thiazole-4-carboxylic acid as a white solid.

Workup

  1. customInto a 50-mL round-bottom flask, was placed
  2. concentrationThe resulting mixture was concentrated
  3. additionadded 30 mL of petroleum ether slowly when it
  4. filtrationThe solids were collected by filtration
  5. washwashed with petroleum ether
  6. customThis resulted in 1.35 g (86%) of 3-(4-chlorophenyl)-1,2-thiazole-4-carboxylic acid as a white solid

Sources & evidence

ORD record
ord-51aad4adf3bc4e138a695c90eaca1686
Source dataset
uspto-grants-2015_06
Patent number
US09067898B1

Reaction notes

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