反应详情

温度

200 °C

Into a 50-mL round-bottom flask, was placed 3-(4-chlorophenyl)-1,2-thiazole-4,5-dicarboxylic acid (1.8697 g, 6.74 mmol, 1.00 equiv), 1,2-dichlorobenzene (20 mL). The resulting solution was stirred for 20 min at 200° C. The resulting mixture was concentrated, and then added 30 mL of petroleum ether slowly when it is hot. The solids were collected by filtration, washed with petroleum ether. This resulted in 1.35 g (86%) of 3-(4-chlorophenyl)-1,2-thiazole-4-carboxylic acid as a white solid.

1. customInto a 50-mL round-bottom flask, was placed
2. concentrationThe resulting mixture was concentrated
3. additionadded 30 mL of petroleum ether slowly when it
4. filtrationThe solids were collected by filtration
5. washwashed with petroleum ether
6. customThis resulted in 1.35 g (86%) of 3-(4-chlorophenyl)-1,2-thiazole-4-carboxylic acid as a white solid