Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoate → HCID 90418134, compound

HRID 2177231Notes

Reaction equation

HRID 2177231 reaction equation
Cl[CH2:2][C:3]1[C:4]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH3:17])=[CH:12][CH:11]=2)=[N:5][S:6][C:7]=1[CH:8]=[CH2:9].[OH:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])=[C:21]([CH3:32])[C:20]=1[CH3:33]>>[CH:8]([C:7]1[S:6][N:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH3:17])=[CH:12][CH:11]=2)[C:3]=1[CH2:2][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])=[C:21]([CH3:32])[C:20]=1[CH3:33])=[CH2:9]

Participants

3

Reactant 2

HCID 58566491Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoateHCID 90417902HCID 90417902, compound

Product 1

HCID 90418134HCID 90418134, compound

Procedure

The title compound was prepared according to the procedure described in Example 122 following Step 5 by coupling of 4-(chloromethyl)-3-(4-ethylphenyl)-5-vinylisothiazole with ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoate to afford the desired product as a yellow oil. Mass spectrum (ESI, m/z): Calcd. for C27H31NO3S, 450.2 (M−H). found 450.2.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-1b76e2759c1043a2aa11b160106f157d
Source dataset
uspto-grants-2015_06
Patent number
US09067898B1

Reaction notes

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