Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoate → HCID 90418067, compound

HRID 2177238Notes

Reaction equation

HRID 2177238 reaction equation
CS([O:5][CH2:6][C:7]1[C:8]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=2)=[N:9][S:10][C:11]=1[O:12][CH3:13])(=O)=O.O[C:23]1[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][C:31]([O:33]CC)=[O:32])=[C:25]([CH3:36])[C:24]=1[CH3:37]>>[CH2:20]([C:17]1[CH:18]=[CH:19][C:14]([C:8]2[C:7]([CH2:6][O:5][C:23]3[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][C:31]([OH:33])=[O:32])=[C:25]([CH3:36])[C:24]=3[CH3:37])=[C:11]([O:12][CH3:13])[S:10][N:9]=2)=[CH:15][CH:16]=1)[CH3:21]

Participants

3

Reactant 2

HCID 58566491Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoateHCID 90418498HCID 90418498, compound

Product 1

HCID 90418067HCID 90418067, compound

Procedure

The title compound was prepared according to the procedure described in Example 1 following Steps 2-6 by coupling of (3-(4-ethylphenyl)-5-methoxyisothiazol-4-yl)methyl methanesulfonate and ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoate followed by hydrolysis to afford the desired product as an off-white solid.

Workup

  1. customThe title compound was prepared
  2. customfollowed by hydrolysis

Sources & evidence

ORD record
ord-dce31a5bde7c43238dabedbb48a23645
Source dataset
uspto-grants-2015_06
Patent number
US09067898B1

Reaction notes

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