Aluminium lithium hydride → HCID 90418400, compound

HRID 2177247Notes

Reaction equation

HRID 2177247 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:18]([CH2:19][O:20][C:21]3[C:26]([F:27])=[CH:25][C:24]([CH2:28][CH2:29][C:30](OCC)=[O:31])=[C:23]([CH3:35])[C:22]=3[F:36])=[C:17]([C:37]([F:40])([F:39])[F:38])[S:16][N:15]=2)=[CH:10][CH:9]=1>>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:18]([CH2:19][O:20][C:21]3[C:26]([F:27])=[CH:25][C:24]([CH2:28][CH2:29][CH2:30][OH:31])=[C:23]([CH3:35])[C:22]=3[F:36])=[C:17]([C:37]([F:39])([F:40])[F:38])[S:16][N:15]=2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 90418703Ethyl 3-(4-((3-(4-chlorophenyl)-5-(trifluoromethyl)isothiazol-4-yl)methoxy)-3,5-difluoro-2-methylphenyl)propanoate

Product 1

HCID 90418400HCID 90418400, compound

Procedure

The title compound was prepared according to the procedure described in Example 111 by LAH reduction of ethyl 3-(4-((3-(4-chlorophenyl)-5-(trifluoromethyl)isothiazol-4-yl)methoxy)-3,5-difluoro-2-methylphenyl)propanoate to afford the desired product as an off-white solid. 1H NMR (400 MHz, CDCl3) δ 7.78 (d, J=7.0 Hz, 2H), 7.42 (d, J=7.5 Hz, 2H), 6.68 (d, J=8.0 Hz, 1H), 5.02 (s, 2H), 3.62 (m, 2H), 2.62 (m, 2H), 2.12 (s, 3H), 1.75 (m, 2H), 1.55 (br, s, 1H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-2f0296fb0ceb4eaeaf824f4f51025ba6
Source dataset
uspto-grants-2015_06
Patent number
US09067898B1

Reaction notes

Loading…