Sulfuric Acid → 3,5-Dichloro-1,2-thiazole-4-carboxamide

HRID 2177266Notes

Reaction equation

HRID 2177266 reaction equation
[Cl:1][C:2]1[S:6][N:5]=[C:4]([Cl:7])[C:3]=1[C:8]#[N:9].S(=O)(=O)(O)[OH:11]>>[Cl:7][C:4]1[C:3]([C:8]([NH2:9])=[O:11])=[C:2]([Cl:1])[S:6][N:5]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 305706Dichloro-1,2-thiazole-4-carbonitrile

Product 1

HCID 3057083,5-Dichloro-1,2-thiazole-4-carboxamide

Conditions

Temperature
110 °C

Procedure

Into a 50-mL round-bottom flask, was placed dichloro-1,2-thiazole-4-carbonitrile (3.7 g, 20.67 mmol, 1.00 equiv), sulfuric acid (15 mL). The resulting solution was stirred for 2 h at 110° C. The solution was used for the next step directly.

Workup

  1. customInto a 50-mL round-bottom flask, was placed

Sources & evidence

ORD record
ord-cc8b13e889e5424b93e0953c22e48cbb
Source dataset
uspto-grants-2015_06
Patent number
US09067898B1

Reaction notes

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