反应详情

温度

50 °C

NaNO2 (1 g, 14.49 mmol, 1.13 equiv), water (30 ml), dichloro-1,2-thiazole-4-carboxamide (2 g, 10.15 mmol, 1.00 equiv) was added to the sulfuric acid solution of the 3,5-dichloroisothiazole-4-carboxamide. The resulting solution was stirred for 30 min at 50° C. The resulting solution was extracted with 3×30 mL of dichloromethane and the organic layers combined and dried over anhydrous sodium sulfate and concentrated. This resulted in 400 mg (crude) of dichloro-1,2-thiazole-4-carboxylic acid as a brown solid.

1. extractionThe resulting solution was extracted with 3×30 mL of dichloromethane
2. dry with materialdried over anhydrous sodium sulfate
3. concentrationconcentrated
4. customThis resulted in 400 mg (crude) of dichloro-1,2-thiazole-4-carboxylic acid as a brown solid