HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boronic acid, (4-ethylphenyl)- → HCID 90418009, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boronic acid, (4-ethylphenyl)- | HCID 2734352 | — |
| Reactant | Methyl 3-hydroxy-5-(trifluoromethyl)thiophene-2-carboxylate | HCID 2759855 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | HCID 90418823 | HCID 90418823 | — |
| Product | HCID 90418009 | HCID 90418009 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Example 208 starting from methyl 3-hydroxy-5-(trifluoromethyl)thiophene-2-carboxylate and by coupling of methyl 5-(trifluoromethyl)-3-(((trifluoromethyl)sulfonyl)oxy)thiophene-2-carboxylate and 4-ethylphenyl boronic acid followed by LAH reduction to afford the desired product as an off-white oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067898B1 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-fcf2d3e833f84685a611992a55e7685e |
| Source note | uspto-grants-2015_06 |