Ethyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoate → HCID 85473232, compound

HRID 2177355Notes

Reaction equation

C(C1C=CC(C2C=C(C(F)(F)F)SC=2CO)=CC=1)C.OC1C=CC(CCC(OCC)=O)=C(F)C=1F.[CH2:36]([C:38]1[CH:43]=[CH:42][C:41]([C:44]2[CH:48]=[C:47]([C:49]([F:52])([F:51])[F:50])[S:46][C:45]=2[CH2:53][O:54][C:55]2[CH:60]=[CH:59][C:58]([CH2:61][CH2:62][C:63]([O:65]CC)=[O:64])=[C:57]([F:68])[C:56]=2[F:69])=[CH:40][CH:39]=1)[CH3:37]>>[CH2:36]([C:38]1[CH:39]=[CH:40][C:41]([C:44]2[CH:48]=[C:47]([C:49]([F:52])([F:50])[F:51])[S:46][C:45]=2[CH2:53][O:54][C:55]2[CH:60]=[CH:59][C:58]([CH2:61][CH2:62][C:63]([OH:65])=[O:64])=[C:57]([F:68])[C:56]=2[F:69])=[CH:42][CH:43]=1)[CH3:37]

Participants

Reactant 3

HCID 90404786Ethyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoate

HCID 90418009HCID 90418009, compound

HCID 90418428HCID 90418428, compound

Product 1

HCID 85473232HCID 85473232, compound

Procedure

The title compound was prepared according to the procedure described in Example 207 by coupling of (3-(4-ethylphenyl)-5-(trifluoromethyl)thiophen-2-yl)methanol and ethyl 3-(4-hydroxy-2,3-difluoro phenyl)propanoate followed by hydrolysis of ethyl 3-(4-((3-(4-ethylphenyl)-5-(trifluoromethyl)thiophen-2-yl)methoxy)-2,3-difluorophenyl)propanoate to afford the desired product as an off-white solid.

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-914f695b602842789bfa74019982f587
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09067898B1

Reaction notes

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