Boronic acid, (4-ethylphenyl)- → HCID 90418140, compound

HRID 2177367Notes

Reaction equation

HRID 2177367 reaction equation
Br[C:2]1[S:3][C:4]([CH3:16])=[C:5]([C:12]([F:15])([F:14])[F:13])[C:6]=1[C:7]([O:9]CC)=O.[CH2:17]([C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1)[CH3:18]>>[CH2:17]([C:19]1[CH:24]=[CH:23][C:22]([C:2]2[S:3][C:4]([CH3:16])=[C:5]([C:12]([F:13])([F:14])[F:15])[C:6]=2[CH2:7][OH:9])=[CH:21][CH:20]=1)[CH3:18]

Participants

3

Reactant 2

HCID 2734352Boronic acid, (4-ethylphenyl)-HCID 90418452HCID 90418452, compound

Product 1

HCID 90418140HCID 90418140, compound

Procedure

The title compound was prepared according to the procedure described in Example 220 by Suzuki coupling of ethyl 2-bromo-5-methyl-4-(trifluoromethyl)thiophene-3-carboxylate and 4-ethyl-phenylboronic acid followed by synthetic steps to afford the desired product as a yellow oil.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-643156ef648044818fd9c58cdbb55c72
Source dataset
uspto-grants-2015_06
Patent number
US09067898B1

Reaction notes

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