Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoate → HCID 85472088, compound

HRID 2177369Notes

Reaction equation

HRID 2177369 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:10][C:11]([CH3:20])=[C:12]([C:16]([F:19])([F:18])[F:17])[C:13]=2[CH2:14][OH:15])=[CH:5][CH:4]=1)[CH3:2].O[C:22]1[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][C:30]([O:32]CC)=[O:31])=[C:24]([CH3:35])[C:23]=1[CH3:36].C(C1C=CC(C2SC(C)=C(C(F)(F)F)C=2COC2C(F)=CC(CCC(OCC)=O)=CC=2F)=CC=1)C>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[S:10][C:11]([CH3:20])=[C:12]([C:16]([F:19])([F:17])[F:18])[C:13]=2[CH2:14][O:15][C:22]2[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[C:24]([CH3:35])[C:23]=2[CH3:36])=[CH:7][CH:8]=1)[CH3:2]

Participants

4

Reactant 3

HCID 58566491Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoateHCID 90418140HCID 90418140, compoundHCID 90418143HCID 90418143, compound

Product 1

HCID 85472088HCID 85472088, compound

Procedure

The title compound was prepared according to the procedure described in Example 220 by coupling of [2-(4-ethylphenyl)-5-methyl-4-(trifluoromethyl)thiophen-3-yl]methanol and ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoate followed by hydrolysis of ethyl 3-(4-((2-(4-ethyl phenyl)-5-methyl-4-(trifluoromethyl)thiophen-3-yl)methoxy)-3,5-difluorophenyl)propanoate to afford the desired product as an off-white solid.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-ad59b5b1438c4bdb8942d734433f853c
Source dataset
uspto-grants-2015_06
Patent number
US09067898B1

Reaction notes

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