Aluminium lithium hydride → HCID 85471957, compound

HRID 2177371Notes

Reaction equation

HRID 2177371 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:15]([CH2:23][O:24][C:25]3[C:30]([F:31])=[CH:29][C:28]([CH2:32][CH2:33][C:34](OCC)=[O:35])=[C:27]([F:39])[C:26]=3[F:40])=[C:16]([C:19]([F:22])([F:21])[F:20])[S:17][CH:18]=2)=[CH:10][CH:9]=1>>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[C:15]([CH2:23][O:24][C:25]3[C:30]([F:31])=[CH:29][C:28]([CH2:32][CH2:33][CH2:34][OH:35])=[C:27]([F:39])[C:26]=3[F:40])=[C:16]([C:19]([F:21])([F:22])[F:20])[S:17][CH:18]=2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 90418875HCID 90418875, compound

Product 1

HCID 85471957HCID 85471957, compound

Procedure

The title compound was prepared according to the procedure described in Example 223 by LAH reduction of ethyl 3-(4-((4-(4-chlorophenyl)-2-(trifluoromethyl)thiophen-3-yl)methoxy)-2,3,5-trifluorophenyl)propanoate to give the desired product as off-white oil. 1H NMR (400 MHz, CDCl3) δ 7.50 (d, J=7.5 Hz, 2H), 7.45 (s, 1H), 7.42 (d, J=8.0 Hz, 2H), 6.72 (m, 1H), 5.06 (s, 2H), 3.70 (t, J=9.0 Hz, 2H), 2.72 (t, J=9.1 Hz, 2H), 1.86 (m, 2H), 1.60 (s, 1H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-4bf96248d2934b3491e77cdb7ba4c6ab
Source dataset
uspto-grants-2015_06
Patent number
US09067898B1

Reaction notes

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