Aluminium lithium hydride → HCID 85473230, compound

HRID 2177375Notes

Reaction equation

HRID 2177375 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[Cl:7][C:8]1[S:12][C:11]([CH2:13][O:14][C:15]2[C:20]([F:21])=[CH:19][C:18]([CH2:22][CH2:23][C:24](OCC)=[O:25])=[CH:17][C:16]=2[F:29])=[C:10]([C:30]2[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=2)[CH:9]=1>>[Cl:7][C:8]1[S:12][C:11]([CH2:13][O:14][C:15]2[C:16]([F:29])=[CH:17][C:18]([CH2:22][CH2:23][CH2:24][OH:25])=[CH:19][C:20]=2[F:21])=[C:10]([C:30]2[CH:31]=[CH:32][C:33]([Cl:36])=[CH:34][CH:35]=2)[CH:9]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 90418006HCID 90418006, compound

Product 1

HCID 85473230HCID 85473230, compound

Procedure

The title compound was prepared according to the procedure described in Example 222 by LAH reduction of ethyl 3-(4-((5-chloro-3-(4-chlorophenyl)thiophen-2-yl)methoxy)-3,5-difluoro phenyl)propanoate to give the desired product as off-white oil. 1H NMR (300 MHz, CD3OD) δ 7.42-7.52 (m, 4H), 7.07 (s, 1H), 6.85 (d, J=9.6 Hz, 2H), 5.11 (s, 2H), 3.58 (t, J=7.8 Hz, 2H), 2.66 (t, J=6.0 Hz, 2H), 1.79-1.86 (m, 2H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-8dc0adf5e37c49a7a9bbfd6f96d2ed19
Source dataset
uspto-grants-2015_06
Patent number
US09067898B1

Reaction notes

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