HCID 118184908, compound → HCID 118184921, compound

Participants

Reaction Steps

The title compound 277 was prepared according to the procedure described in Example 127, following Steps 6-7, coupling (3-chloro-5-(p-tolyl)isothiazol-4-yl)methanol with ethyl 3-(1,1-difluoro-7-hydroxy-2,3-dihydro-1H-inden-4-yl)propanoate. Upon hydrolysis, compound 277 was afforded as an off-white solid. 1H NMR (300 MHz, CD3OD) δ: 7.43 (d, J=8.1 Hz, 2H), 7.33 (d, J=7.8 Hz, 2H), 7.16 (d, J=8.1 Hz, 1H), 7.00 (d, J=8.4 Hz, 1H), 5.07 (s, 2H), 3.06 (t, J=7.8 Hz, 2H), 2.78-2.84 (m, 2H), 2.40-2.67 (m, 4H), 2.37 (s, 3H). 19F NMR (300 MHz, CD3OD) δ: −84.86. Mass spectrum (ESI, m/z): Calcd. for C23H20ClF2NO3S, 462.1 (M−H). found 462.0.

Provenance & Evidence