Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoate → HCID 118184928, compound

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Reaction Steps

The title compound was prepared according to the procedure described in Example 1 starting from 4-[4-(hydroxymethyl)-5-(trifluoromethyl)-1,2-thiazol-3-yl]benzonitrile, following Steps 4-6 and coupling with ethyl 3-(2,3-dimethyl-4-hydroxyphenyl)-propanoate. Upon hydrolysis, compound 264 was afforded as an off-white solid. 1H NMR (400 MHz, CDCl3) δ: 7.85 (d, J=8.4 Hz, 2H), 7.73 (d, J=8.4 Hz, 2H), 6.99 (d, J=8.6 Hz, 1H), 6.67 (d, J=8.6 Hz, 1H), 5.01 (s, 2H), 2.96 (t, J=7.8 Hz, 2H), 2.62 (t, J=7.8 Hz, 2H), 2.24 (s, 3H), 2.00 (s, 3H). 19F NMR (400 MHz, CDCl3) δ: −55.39. Mass spectrum (ESI, m/z): Calcd. for C23H19F3N2O3S, 459.0 (M−H). found 459.0.

Provenance & Evidence