Methanol → HCID 118184922, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 1 Step 6 by hydrolysis of ethyl 3-(4-((3-(5-chlorothiazol-2-yl)-5-(trifluoromethyl)isothiazol-4-yl)methoxy)-3,5-difluorophenyl)propanoate in MeOH instead of THF to afford compound 267 as an off-white solid. 1H NMR (400 MHz, CDCl3) δ: 7.91 (s, 1H), 6.75 (d, J=8.0 Hz, 2H), 5.26 (s, 2H), 4.12 (s, 3H), 2.88 (t, J=6.8 Hz, 2H), 2.62 (t, J=6.0 Hz, 2H). Mass spectrum (ESI, m/z): Calcd. for C18H13F5N2O4S2, 481.0 (M+H). found 481.0.

Provenance & Evidence