L-Malic Acid → Sunitinib Malate

HRID 2177455Notes

Reaction equation

HRID 2177455 reaction equation
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[C:30]([OH:38])(=[O:37])[C@H:31]([CH2:33][C:34]([OH:36])=[O:35])[OH:32]>O>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[CH2:33]([C:34]([OH:36])=[O:35])[C@H:31]([OH:32])[C:30]([OH:38])=[O:37]

Participants

4

Reactant 2

HCID 222656L-Malic AcidHCID 5329102Sunitinib

Product 1

HCID 6456015Sunitinib Malate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Composition L containing Sunitinib base and L-malic acid (10 mg) was weighted into a vial, then 10 μL of water was added and blended was mixed by shaking the vial. The vial was closed and left at ambient temperature for 32 days until drying, obtaining form I.

Workup

  1. additionwas added
  2. additionblended was mixed
  3. customThe vial was closed
  4. customuntil drying
  5. customobtaining form I

Sources & evidence

ORD record
ord-7e03ff8fd74b47e39f984bf81526dd67
Source dataset
uspto-grants-2015_06
Patent number
US09067915B2

Reaction notes

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