L-Malic Acid → Sunitinib Malate

HRID 2177457Notes

Reaction equation

HRID 2177457 reaction equation
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[C:30]([OH:38])(=[O:37])[C@H:31]([CH2:33][C:34]([OH:36])=[O:35])[OH:32]>C(O)C>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[CH2:33]([C:34]([OH:36])=[O:35])[C@H:31]([OH:32])[C:30]([OH:38])=[O:37]

Participants

4

Reactant 2

HCID 222656L-Malic AcidHCID 5329102Sunitinib

Product 1

HCID 6456015Sunitinib Malate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Composition L containing Sunitinib base and L-malic acid (10 mg) was weighed into a vial, then 10 μL of ethanol was added and the blend was mixed by shaking the vial. The vial was closed and left at ambient temperature for 3 days until drying, obtaining form I.

Workup

  1. additionwas added
  2. additionthe blend was mixed
  3. customThe vial was closed
  4. customuntil drying
  5. customobtaining form I

Sources & evidence

ORD record
ord-0d3e307a05de4fce8236db9420113095
Source dataset
uspto-grants-2015_06
Patent number
US09067915B2

Reaction notes

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