L-Malic Acid → Sunitinib Malate

Participants

Reaction Steps

A mixture (280 mg) of Sunitinib base (form VIII and L-malic acid in molar ratio 1:1 was prepared. The aforementioned Sunitinib base and L-malic acid were powdered separately by a mortar and pestle. The powdered Sunitinib base (210 mg) was weighed into a vial, and then the powdered L-malic acid (70 mg) was added into the same vial. The mixture was then homogenized by means of shaking the vial in hand. The mixture (10 mg) was weighed into a vial, then 10 μL of methanol was added and the blend was mixed by shaking the vial. The vial was closed and left at ambient temperature for 3 days until drying, obtaining form I.

Provenance & Evidence