L-Malic Acid → Sunitinib Malate

HRID 2177461Notes

Reaction equation

HRID 2177461 reaction equation
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[C:30]([OH:38])(=[O:37])[C@H:31]([CH2:33][C:34]([OH:36])=[O:35])[OH:32]>O>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[CH2:33]([C:34]([OH:36])=[O:35])[C@H:31]([OH:32])[C:30]([OH:38])=[O:37]

Participants

4

Reactant 2

HCID 222656L-Malic AcidHCID 5329102Sunitinib

Product 1

HCID 6456015Sunitinib Malate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Composition H, I or K containing Sunitinib base and L-malic acid. (10 mg) was poured into a glass vial and about 10 μl of water was added. The vial was closed and the suspension was left at ambient temperature for 3 days until drying, obtaining form I.

Workup

  1. additionwas added
  2. customThe vial was closed
  3. customuntil drying
  4. customobtaining form I

Sources & evidence

ORD record
ord-f157e408d06946d5b5b60b69885e02ff
Source dataset
uspto-grants-2015_06
Patent number
US09067915B2

Reaction notes

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