Diisopropyl Ether → Sunitinib

Participants

Reaction Conditions

Reaction Steps

Sunitinib acetate (1 g) was suspended in absolute ethanol (20 ml) under stirring at 20° C. and the mixture was heated to 40° C. Then diisopropyl ether (40 ml) was added within 10 min with stirring, the mixture was cooled to −10° C. in 2 hours and after 2 h at −10° C. the solid was filtered and dried for 16 hours under vacuum at 75° C. obtaining 0.8 g of orange solid.

Provenance & Evidence