HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 217749Generated: October 29, 2026
Hydrochloric Acid → 3-Tert-butyl-5-(2-methoxyethoxy)benzoic acid
https://huagongshe.com/reaction/217749
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 3-tert-butyl-5-(2-methoxyethoxy)benzoate | HCID 58136955 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Tert-butyl-5-(2-methoxyethoxy)benzoic acid | HCID 58136880 | 100.3% |
Reaction Steps
Methyl 3-tert-butyl-5-(2-methoxyethoxy)benzoate (O5.043; 2.0 g) was dissolved in methanol (30 ml) and THF (60 ml), and lithium hydroxide solution (30 ml, 1 M in water) was added. The mixture was heated to 40° C. and stirred for 3 h. Then the organic solvents were drawn off and the aqueous phase was adjusted to pH 3 with 1 N hydrochloric acid. The mixture was extracted with EA, dried, filtered and concentrated. 1.9 g of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08198272B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-8272988412264a5993c4189f89fd001a |
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| Source note | uspto-grants-2012_06 |
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